Structural basis of DNA quadruplex recognition by an acridine drug.
نویسندگان
چکیده
The crystal structure of a complex between the bimolecular human telomeric quadruplex d(TAGGGTTAGGGT)2 and the experimental anticancer drug BRACO-19, has been determined, to 2.5 A resolution. The binding site for the BRACO-19 molecule is at the interface of two parallel-folded quadruplexes, sandwiched between a G-tetrad surface and a TATA tetrad, and held in the site by networks of water molecules. The structure rationalizes the existing structure-activity data and provides a starting-point for the structure-based design of quadruplex-binding ligands
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 130 21 شماره
صفحات -
تاریخ انتشار 2008